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Issue 12, 2012
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Zirconium phosphate nano-platelets: a novel platform for drug delivery in cancer therapy

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Abstract

Doxorubicin was intercalated into novel zirconium phosphate nano-platelets (ZrP). The obtained doxorubicin intercalated ZrP nano-platelets had an impressive 34.9% (w/w) drug loading. We used this material to deliver doxorubicin to breast cancer cells (MCF-7). Cellular studies with MCF-7 cells showed higher uptake and cytotoxicity of doxorubicin loaded ZrP compared to free doxorubicin.

Graphical abstract: Zirconium phosphate nano-platelets: a novel platform for drug delivery in cancer therapy

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Publication details

The article was received on 06 Oct 2011, accepted on 12 Dec 2011 and first published on 13 Dec 2011


Article type: Communication
DOI: 10.1039/C2CC16218K
Citation: Chem. Commun., 2012,48, 1754-1756
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    Zirconium phosphate nano-platelets: a novel platform for drug delivery in cancer therapy

    A. Díaz, V. Saxena, J. González, A. David, B. Casañas, C. Carpenter, J. D. Batteas, J. L. Colón, A. Clearfield and M. Delwar Hussain, Chem. Commun., 2012, 48, 1754
    DOI: 10.1039/C2CC16218K

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