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Issue 17, 2012
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Protein crystal structures with ferrocene and ruthenocene-based enzyme inhibitors

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Abstract

We have determined the protein X-ray crystal structures of four organometallic inhibitors in complex with their target enzyme carbonic anhydrase II. The barrel-shaped hydrophobic ferrocene and ruthenocene moieties have provided a structure-based avenue to better occupy the hydrophobic binding patch within the enzyme active site.

Graphical abstract: Protein crystal structures with ferrocene and ruthenocene-based enzyme inhibitors

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Publication details

The article was received on 12 Sep 2011, accepted on 23 Dec 2011 and first published on 18 Jan 2012


Article type: Communication
DOI: 10.1039/C2CC15625C
Citation: Chem. Commun., 2012,48, 2328-2330
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    Protein crystal structures with ferrocene and ruthenocene-based enzyme inhibitors

    A. J. Salmon, M. L. Williams, A. Hofmann and S. Poulsen, Chem. Commun., 2012, 48, 2328
    DOI: 10.1039/C2CC15625C

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