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Issue 1, 2012
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Decarboxylative benzylation and arylation of nitriles

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Abstract

Decarboxylative benzylation of nitriles is achieved via coupling of metallated nitriles with Pd-π-benzyl complexes that are generated in situ from cyanoacetic benzyl esters. In addition, decarboxylative couplings of α,α-disubstituted 2-methylfuranyl cyanoacetates can lead to either decarboxylative arylation or benzylation depending on the reaction conditions.

Graphical abstract: Decarboxylative benzylation and arylation of nitriles

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Publication details

The article was received on 27 Sep 2011, accepted on 12 Oct 2011 and first published on 07 Nov 2011


Article type: Communication
DOI: 10.1039/C1CC16011G
Citation: Chem. Commun., 2012,48, 142-144
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    Decarboxylative benzylation and arylation of nitriles

    A. Recio, III, J. D. Heinzman and J. A. Tunge, Chem. Commun., 2012, 48, 142
    DOI: 10.1039/C1CC16011G

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