Issue 22, 2012

Dual-functional probes towards in vivo studies of brain connectivity and plasticity

Abstract

A Gd3+ based paramagnetic dextran conjugate has been developed, which enables the tracking of neuroanatomical connectivity in the brain by both MR and optical imaging. Cell studies and subsequent in vivo experiments in rodents demonstrate efficient internalisation and transport properties of the new tracer molecule.

Graphical abstract: Dual-functional probes towards in vivo studies of brain connectivity and plasticity

Supplementary files

Article information

Article type
Communication
Submitted
26 Sep 2011
Accepted
10 Nov 2011
First published
01 Dec 2011

Chem. Commun., 2012,48, 2755-2757

Dual-functional probes towards in vivo studies of brain connectivity and plasticity

I. Mamedov, J. Engelmann, O. Eschenko, M. Beyerlein and N. K. Logothetis, Chem. Commun., 2012, 48, 2755 DOI: 10.1039/C1CC15991G

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