Issue 6, 2012

The enantiomers of syn-2,3-difluoro-4-aminobutyric acid elicit opposite responses at the GABAC receptor

Abstract

The conformational behaviour and GABA receptor activity of the different stereoisomers of 2,3-difluoro-4-aminobutyric acid are described. Two enantiomeric GABAC-active ligands are identified, one of which is an agonist while the other is an antagonist. The results support an existing QSAR model of the bioactive geometry of GABA at GABAC.

Graphical abstract: The enantiomers of syn-2,3-difluoro-4-aminobutyric acid elicit opposite responses at the GABAC receptor

Supplementary files

Article information

Article type
Communication
Submitted
20 Sep 2011
Accepted
17 Nov 2011
First published
05 Dec 2011

Chem. Commun., 2012,48, 829-831

The enantiomers of syn-2,3-difluoro-4-aminobutyric acid elicit opposite responses at the GABAC receptor

I. Yamamoto, M. J. T. Jordan, N. Gavande, M. R. Doddareddy, M. Chebib and L. Hunter, Chem. Commun., 2012, 48, 829 DOI: 10.1039/C1CC15816C

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