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Issue 15, 2013
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Palladium catalyzed cyclizations of oximeesters with 1,1-disubstituted alkenes: synthesis of α,α-disubstituted dihydropyrroles and studies towards an asymmetric protocol

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Abstract

We report efficient Pd-catalyzed cyclizations of oximeesters with 1,1-disubstituted alkenes as the basis of a general entry to α,α-disubstituted pyrrolidine derivatives. We also demonstrate that catalytic asymmetric variants of this chemistry are feasible by employing a suitable chiral ligand.

Graphical abstract: Palladium catalyzed cyclizations of oximeesters with 1,1-disubstituted alkenes: synthesis of α,α-disubstituted dihydropyrroles and studies towards an asymmetric protocol

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Publication details

The article was received on 14 Dec 2012, accepted on 04 Jan 2013 and first published on 04 Jan 2013


Article type: Communication
DOI: 10.1039/C2CC38944D
Citation: Chem. Commun., 2013,49, 1521-1523
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    Palladium catalyzed cyclizations of oximeesters with 1,1-disubstituted alkenes: synthesis of α,α-disubstituted dihydropyrroles and studies towards an asymmetric protocol

    A. Faulkner, J. S. Scott and J. F. Bower, Chem. Commun., 2013, 49, 1521
    DOI: 10.1039/C2CC38944D

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