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Issue 14, 2013
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Organocatalytic asymmetric multicomponent reactions of aromatic aldehydes and anilines with β-ketoesters: facile and atom-economical access to chiral tetrahydropyridines

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Abstract

The first catalytic asymmetric pseudo five-component (AB2C2 type) reaction is reported. A spirocyclic chiral phosphoric acid catalyzed one-pot multicomponent reaction of aromatic aldehydes, anilines and β-ketoesters and afforded highly functionalized enantioenriched tetrahydropyridines with high levels of stereocontrol.

Graphical abstract: Organocatalytic asymmetric multicomponent reactions of aromatic aldehydes and anilines with β-ketoesters: facile and atom-economical access to chiral tetrahydropyridines

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Publication details

The article was received on 20 Nov 2012, accepted on 21 Dec 2012 and first published on 03 Jan 2013


Article type: Communication
DOI: 10.1039/C2CC38349G
Citation: Chem. Commun., 2013,49, 1401-1403
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    Organocatalytic asymmetric multicomponent reactions of aromatic aldehydes and anilines with β-ketoesters: facile and atom-economical access to chiral tetrahydropyridines

    X. Li, Y. Zhao, H. Qu, Z. Mao and X. Lin, Chem. Commun., 2013, 49, 1401
    DOI: 10.1039/C2CC38349G

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