Issue 14, 2013
From the journal:

Chemical Communications

Organocatalytic asymmetric multicomponent reactions of aromatic aldehydes and anilines with β-ketoesters: facile and atom-economical access to chiral tetrahydropyridines†

Xuejian Li,a   Yanyan Zhao,a   Haijun Qu,a   Zhenjun Maoa  and  Xufeng Lin*a  

* Corresponding authors

a Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China
E-mail: lxfok@zju.edu.cn

Abstract

The first catalytic asymmetric pseudo five-component (AB2C2 type) reaction is reported. A spirocyclic chiral phosphoric acid catalyzed one-pot multicomponent reaction of aromatic aldehydes, anilines and β-ketoesters and afforded highly functionalized enantioenriched tetrahydropyridines with high levels of stereocontrol.

Graphical abstract: Organocatalytic asymmetric multicomponent reactions of aromatic aldehydes and anilines with β-ketoesters: facile and atom-economical access to chiral tetrahydropyridines

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Article information

DOI
https://doi.org/10.1039/C2CC38349G
Article type
Communication
Submitted
20 Nov 2012
Accepted
21 Dec 2012
First published
03 Jan 2013

Chem. Commun., 2013,49, 1401-1403

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Organocatalytic asymmetric multicomponent reactions of aromatic aldehydes and anilines with β-ketoesters: facile and atom-economical access to chiral tetrahydropyridines

X. Li, Y. Zhao, H. Qu, Z. Mao and X. Lin, Chem. Commun., 2013, 49, 1401 DOI: 10.1039/C2CC38349G

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