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Issue 8, 2013
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Rapid formal hydrolysis of peptide-αthioesters

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In the presence of 2-mercaptoethanol peptide-αthioesters undergo smooth conversion to their corresponding peptide-αcarboxylates. This general and operationally simple reaction extends the utility of a promising new strategy for cleaving resin-bound Boc/benzyl-protected peptides without the use of hydrogen fluoride.

Graphical abstract: Rapid formal hydrolysis of peptide-αthioesters

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Publication details

The article was received on 14 Nov 2012, accepted on 29 Nov 2012 and first published on 29 Nov 2012

Article type: Communication
DOI: 10.1039/C2CC38229F
Citation: Chem. Commun., 2013,49, 786-788
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    Rapid formal hydrolysis of peptide-αthioesters

    Z. P. Gates, J. R. Stephan, D. J. Lee and S. B. H. Kent, Chem. Commun., 2013, 49, 786
    DOI: 10.1039/C2CC38229F

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