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Issue 14, 2013
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Functional conversion of nickel-containing metalloproteins via molecular design: from a truncated acetyl-coenzyme A synthase to a nickel superoxide dismutase

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Abstract

Truncated acetyl-coenzyme A synthase (ACS) was successfully converted into functional nickel superoxide dismutase (Ni-SOD) by molecular design and the designed metalloproteins possess new spectroscopic, structural, and electrochemical characteristics required for catalyzing O2˙ disproportionation, and exhibit impressive Ni-SOD activity.

Graphical abstract: Functional conversion of nickel-containing metalloproteins via molecular design: from a truncated acetyl-coenzyme A synthase to a nickel superoxide dismutase

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Publication details

The article was received on 14 Nov 2012, accepted on 02 Jan 2013 and first published on 03 Jan 2013


Article type: Communication
DOI: 10.1039/C2CC38224E
Citation: Chem. Commun., 2013,49, 1452-1454
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    Functional conversion of nickel-containing metalloproteins via molecular design: from a truncated acetyl-coenzyme A synthase to a nickel superoxide dismutase

    Y. Liu, Q. Wang, Y. Wei, Y. Lin, W. Li, J. Su, Z. Wang, Y. Tian, Z. Huang and X. Tan, Chem. Commun., 2013, 49, 1452
    DOI: 10.1039/C2CC38224E

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