Jump to main content
Jump to site search

Issue 15, 2013
Previous Article Next Article

Insight into the reaction between a primary amine and a cavitand with an introverted aldehyde group: an enzyme-like mechanism

Author affiliations

Abstract

Density functional theory investigations reveal that a cavitand with an introverted aldehyde group not only provides the host–guest interaction for preorganizing the substrate and stabilizing the hemiaminal intermediate, but also acts as an acid/base catalyst in the subsequent dehydration step in its reaction with a primary amine.

Graphical abstract: Insight into the reaction between a primary amine and a cavitand with an introverted aldehyde group: an enzyme-like mechanism

Back to tab navigation

Supplementary files

Publication details

The article was received on 12 Nov 2012, accepted on 07 Jan 2013 and first published on 07 Jan 2013


Article type: Communication
DOI: 10.1039/C2CC38165F
Citation: Chem. Commun., 2013,49, 1542-1544
  •   Request permissions

    Insight into the reaction between a primary amine and a cavitand with an introverted aldehyde group: an enzyme-like mechanism

    L. Xu, S. Hua and S. Li, Chem. Commun., 2013, 49, 1542
    DOI: 10.1039/C2CC38165F

Search articles by author

Spotlight

Advertisements