Pattern-based sensing of nucleotides with functionalized gold nanoparticles

Cristian Pezzato; Boram Lee; Kay Severin; Leonard J. Prins

doi:10.1039/C2CC38058G

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Chemical Communications

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Pattern-based sensing of nucleotides with functionalized gold nanoparticles

Cristian Pezzato,^a Boram Lee,^b Kay Severin^b and Leonard J. Prins*^a

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Department of Chemical Sciences, University of Padova, via Marzolo 1, 35131 Padova, Italy
E-mail: leonard.prins@unipd.it

Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

Chem. Commun., 2013,49, 469-471

DOI: 10.1039/C2CC38058G
Received 07 Nov 2012, Accepted 20 Nov 2012
First published online 21 Nov 2012

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A sensing system has been obtained by self-assembly of multiple fluorescent indicators and monolayer protected gold nanoparticles. The system is able to discriminate between each of the eight nucleotides NDP and NTP (N = A, T, G, C) in a quantitative manner at micromolar concentrations.

Abstract from Analytical Abstracts 2013

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