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Issue 14, 2013
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Palladium–copper-cocatalyzed intramolecular oxidative coupling: an efficient and atom-economical strategy for the synthesis of 3-acylindoles

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Abstract

A new and efficient catalytic approach to the synthesis of 3-acylindoles under Pd–Cu-cocatalyzed oxidative conditions is demonstrated. tert-Butyl hydroperoxide (TBHP) acts not only as the oxidant, but also as an oxygen source in the approach. The process allows quick and atom-economical assembly of 3-acylindoles from readily available starting materials and tolerates a broad range of functional groups.

Graphical abstract: Palladium–copper-cocatalyzed intramolecular oxidative coupling: an efficient and atom-economical strategy for the synthesis of 3-acylindoles

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Publication details

The article was received on 27 Oct 2012, accepted on 20 Dec 2012 and first published on 03 Jan 2013


Article type: Communication
DOI: 10.1039/C2CC37805A
Citation: Chem. Commun., 2013,49, 1410-1412
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    Palladium–copper-cocatalyzed intramolecular oxidative coupling: an efficient and atom-economical strategy for the synthesis of 3-acylindoles

    X. Xia, L. Zhang, X. Song, Y. Niu, X. Liu and Y. Liang, Chem. Commun., 2013, 49, 1410
    DOI: 10.1039/C2CC37805A

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