Redox active metals (Fe and Cu) and cofactors (heme) bind to Aβ peptides and react with O2 in their reduced state leading to oxidative stress in the brain. In this study we cryogenically trap and characterize a Fe–O2 intermediate, using resonance Raman spectroscopy, involved in reactive oxygen species formation by Aβ peptides. This is the first reaction intermediate relevant to Alzheimer's disease to be reported.
Chemical Communications
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