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Issue 6, 2013
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Gd3+ cFLFLFK conjugate for MRI: a targeted contrast agent for FPR1 in inflammation

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Abstract

Formyl Peptide Receptors (FPRs) are vital in the host inflammatory response, playing an important regulatory role in multiple diseases. A Gd(III) DOTA conjugate of cFLFLFK has been synthesised which targets and visualises FPR1 upon leukocytes in the inflammatory response via magnetic resonance imaging for the first time.

Graphical abstract: Gd3+ cFLFLFK conjugate for MRI: a targeted contrast agent for FPR1 in inflammation

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Publication details

The article was received on 12 Oct 2012, accepted on 26 Nov 2012 and first published on 27 Nov 2012


Article type: Communication
DOI: 10.1039/C2CC37460A
Citation: Chem. Commun., 2013,49, 564-566
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    Gd3+ cFLFLFK conjugate for MRI: a targeted contrast agent for FPR1 in inflammation

    G. J. Stasiuk, H. Smith, M. Wylezinska-Arridge, J. L. Tremoleda, W. Trigg, S. K. Luthra, V. M. Iveson, F. N. E. Gavins and N. J. Long, Chem. Commun., 2013, 49, 564
    DOI: 10.1039/C2CC37460A

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