A cytotoxic gold(III) complex of meso-tetraphenylporphyrin ([Au(TPP)]Cl, denoted gold-1a) blocks the self-renewal ability of cancer stem-like cells and shows appealing safety pharmacological profiles in rodents.
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A gold(III) porphyrin complex as an anti-cancer candidate to inhibit growth of cancer-stem cells
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a
Department of Chemistry, State Key Laboratory of Synthetic Chemistry, and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong
E-mail: rwysun@hku.hk; cmche@hku.hk ;
Fax: +852-28592154
E-mail: rwysun@hku.hk; cmche@hku.hk ;
Fax: +852-28592154
b
School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong
c
Division of Neurosurgery, Department of Surgery, The Chinese University of Hong Kong, Shatin, Hong Kong
Chem. Commun., 2013,49, 4364-4366
DOI: 10.1039/C2CC37366A
Received 09 Oct 2012, Accepted 15 Nov 2012
First published online 16 Nov 2012
This article is part of themed collection:
Emerging Investigators 2013
Chemical Communications
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