A formal γ-alkynylation of ketones via Pd-catalyzed C–C bond-cleavage is presented. The method allows for the coupling of tert-cyclobutanols and bromoacetylenes, giving access to versatile alkynes that are beyond reach otherwise.
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Formal γ-alkynylation of ketones via Pd-catalyzed C–C cleavage
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Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans 16, Tarragona, Spain
E-mail: rmartinromo@iciq.es ;
Tel: +34 977920248
E-mail: rmartinromo@iciq.es ;
Tel: +34 977920248
Chem. Commun., 2013,49, 4286-4288
DOI: 10.1039/C2CC37281A
Received 05 Oct 2012, Accepted 29 Oct 2012
First published online 30 Oct 2012
This article is part of themed collection:
Emerging Investigators 2013
Chemical Communications
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