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CAS Key Laboratory for Biological Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, 11 Beiyijie, Beijing 100190, China
; Fax: +86 10-62656765
; Tel: +86 10-82545569
Unmodified gold nanoparticles (GNPs) can be wrapped with long genomic single- and double-stranded DNA (ssDNA and dsDNA) molecules produced by asymmetric polymerase chain reaction (As-PCR). More importantly, the DNA–Au interaction can be utilized for colorimetric detection of a specific nucleic acid sequence in clinical samples.
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