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Issue 97, 2012
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Clicked europium dipicolinate complexes for protein X-ray structure determination

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Abstract

New trisdipicolinic acid–lanthanide complexes are reported as phasing agents for X-ray crystallography of proteins. It is demonstrated that CuAAC modifications allow protein co-crystallization with low concentration of lanthanide complexes leading to an accurate structure determination.

Graphical abstract: Clicked europium dipicolinate complexes for protein X-ray structure determination

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Publication details

The article was received on 26 Sep 2012, accepted on 23 Oct 2012 and first published on 23 Oct 2012


Article type: Communication
DOI: 10.1039/C2CC36982F
Citation: Chem. Commun., 2012,48, 11886-11888
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    Clicked europium dipicolinate complexes for protein X-ray structure determination

    R. Talon, L. Nauton, J. Canet, R. Kahn, E. Girard and A. Gautier, Chem. Commun., 2012, 48, 11886
    DOI: 10.1039/C2CC36982F

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