without changing your settings we'll assume you are happy to receive all RSC cookies.
You can change your cookie settings by navigating to our Privacy and Cookies page and following the instructions. These instructions
are also obtainable from the privacy link at the bottom of any RSC page.
A highly efficient macrocyclization reaction has been developed via the palladium-catalyzed C–H arylation of the side-chains of tryptophan with halophenyl-containing amino acids. This method allows for direct access to 15- to 25-membered biaryl macrocycles in 40–75% yield, at moderate concentration, with C–H arylation proceeding exclusively at the C-2 position of the tryptophan indole.
Fetching data from CrossRef. This may take some time to load.