Relaxivity control of magnetic nanoclusters for efficient magnetic relaxation switching assay

Jinmyung Cha; Yong-Su Kwon; Tae-Jong Yoon; Jin-Kyu Lee

doi:10.1039/C2CC36863C

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Chemical Communications

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Relaxivity control of magnetic nanoclusters for efficient magnetic relaxation switching assay

Jinmyung Cha,^a Yong-Su Kwon,^b Tae-Jong Yoon*^b and Jin-Kyu Lee*^a

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Materials Chemistry Laboratory, Department of Chemistry, Seoul National University, Seoul, Korea
E-mail: jinklee@snu.ac.kr ;
Fax: +82 2-882-1080 ;
Tel: +82 2-879-2923

Bio-Nanomaterials Chemistry Laboratory, Department of Applied Bioscience, CHA University, Seoul, Korea
E-mail: tjyoon@cha.ac.kr ;
Fax: +82 31-725-8382 ;
Tel: +82 31-725-8389

Chem. Commun., 2013,49, 457-459

DOI: 10.1039/C2CC36863C
Received 21 Sep 2012, Accepted 16 Oct 2012
First published online 16 Oct 2012

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50 nm Magnetic nanocluster (MNC) was deliberately selected as an efficient probe for the magnetic relaxation switching (MRSw) assay. After surface modification of MNCs with poly(acrylic acid) to give PAA-MNCs, and employing streptavidin–biotin interactions for the MRSw assay model, a few tenths pM concentration of strepavidin could be determined.

Abstract from Analytical Abstracts 2013

50 nm Magnetic nanocluster (MNC) was deliberately selected as an efficient probe for the magnetic relaxation switching (MRSw) assay. After surface modification of MNCs with poly(acrylic acid) to give PAA-MNCs, and employing streptavidin-biotin interactions for the MRSw assay model, a few tenths pM concentration of strepavidin could be determined.

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