A one-step synthesis of two 5-CF3 UDP-sugars is reported. These non-natural sugar-nucleotides are micromolar inhibitors of two different galactosyltransferases.
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One-step synthesis of novel glycosyltransferase inhibitors
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a
Institute of Pharmaceutical Science, School of Biomedical Sciences, King's College London, London, UK
b
Department of Chemistry, School of Biomedical Sciences, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, UK
E-mail: gerd.wagner@kcl.ac.uk ;
Fax: +44 (0)20 7848 4045 ;
Tel: +44 (0)20 7848 4747
E-mail: gerd.wagner@kcl.ac.uk ;
Fax: +44 (0)20 7848 4045 ;
Tel: +44 (0)20 7848 4747
Chem. Commun., 2012,48, 11856-11858
DOI: 10.1039/C2CC36798J
Received 18 Sep 2012, Accepted 23 Oct 2012
First published online 05 Nov 2012
Chemical Communications
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