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Issue 39, 2013
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Organocatalytic asymmetric cyanation of isatin derived N-Boc ketoimines

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Abstract

We report the first catalytic asymmetric cyanation of N-Boc ketoimines, which enables highly enantioselective synthesis of oxindole based α-amino nitriles. An unprecedented tandem aza-Wittig/Strecker reaction is also developed, emerging as a promising strategy for the catalytic asymmetric cyanation of ketoimines formed in situ from achiral ketones.

Graphical abstract: Organocatalytic asymmetric cyanation of isatin derived N-Boc ketoimines

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Publication details

The article was received on 13 Sep 2012, accepted on 09 Oct 2012 and first published on 09 Oct 2012


Article type: Communication
DOI: 10.1039/C2CC36665G
Citation: Chem. Commun., 2013,49, 4421-4423
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    Organocatalytic asymmetric cyanation of isatin derived N-Boc ketoimines

    Y. Liu and J. Zhou, Chem. Commun., 2013, 49, 4421
    DOI: 10.1039/C2CC36665G

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