Enhanced cellular uptake and gene delivery of glioblastoma with deferoxamine-coated nanoparticle/plasmid DNA/branched polyethylenimine composites

Ken Cham-Fai Leung; Chun-Pong Chak; Siu-Fung Lee; Josie M. Y. Lai; Xiao-Ming Zhu; Yi-Xiang J. Wang; Kathy W. Y. Sham; Christopher H. K. Cheng

doi:10.1039/C2CC36663K

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Chemical Communications

Issue 6, 2013

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Enhanced cellular uptake and gene delivery of glioblastoma with deferoxamine-coated nanoparticle/plasmid DNA/branched polyethylenimine composites

Ken Cham-Fai Leung,*^a^b Chun-Pong Chak,^b Siu-Fung Lee,^b Josie M. Y. Lai,^c Xiao-Ming Zhu,^d Yi-Xiang J. Wang,^d Kathy W. Y. Sham^c and Christopher H. K. Cheng*^c

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Institute of Creativity and Department of Chemistry, The Hong Kong Baptist University, Kowloon, Hong Kong SAR, P. R. China
E-mail: cfleung@hkbu.edu.hk ;
Tel: +852 3411 2319

Institute of Molecular Functional Materials and Department of Chemistry, The Chinese University of Hong Kong, NT, Hong Kong SAR, P. R. China

School of Biomedical Sciences, The Chinese University of Hong Kong, NT, Hong Kong SAR, P. R. China

Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, NT, Hong Kong SAR, P. R. China

Chem. Commun., 2013,49, 549-551

DOI: 10.1039/C2CC36663K
Received 13 Sep 2012, Accepted 05 Nov 2012
First published online 05 Nov 2012

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Ternary composite nanomaterials based on deferoxamine-coated superparamagnetic iron oxide nanoparticles (8–10 nm), circular plasmid DNA ( [similar] 4 kb) with fluorescent/luminescent reporter group, and branched polyethylenimine (25 kDa, PDI = 2.5) were prepared and compared in terms of their efficiencies in transfecting brain tumor cells at low concentration.