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Issue 39, 2013
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PNA-based microRNA inhibitors elicit anti-inflammatory effects in microglia cells

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Abstract

Peptide nucleic acid (PNA) inhibitors of miR-221-3p (CU-PNA-221) and miR-466l-3p (CU-PNA-466) demonstrated changes in inflammatory responses. Suppression of inflammatory signalling was unexpected and further investigation led to the identification of calmodulin as a novel target of miRNA-466l-3p. These studies demonstrate that exogenous agents may suppress neuroinflammation mediated by microglial cells.

Graphical abstract: PNA-based microRNA inhibitors elicit anti-inflammatory effects in microglia cells

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Publication details

The article was received on 24 Jul 2012, accepted on 19 Oct 2012, published on 22 Oct 2012 and first published online on 22 Oct 2012


Article type: Communication
DOI: 10.1039/C2CC36540E
Citation: Chem. Commun., 2013,49, 4415-4417
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    PNA-based microRNA inhibitors elicit anti-inflammatory effects in microglia cells

    P. N. Brown and H. Yin, Chem. Commun., 2013, 49, 4415
    DOI: 10.1039/C2CC36540E

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