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Issue 93, 2012
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Formation of chiral fluoroalkyl products through copper-free enantioselective allylic alkylation catalyzed by an NHC ligand

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Abstract

A valuable Cu-free protocol is reported where an NHC ligand has been employed to form quaternary carbon centers bearing fluoroalkyl units. The results obtained, from this allylic substitution, are better in terms of enantioselectivity and regioselectivity compared to the copper catalyzed system.

Graphical abstract: Formation of chiral fluoroalkyl products through copper-free enantioselective allylic alkylation catalyzed by an NHC ligand

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Publication details

The article was received on 06 Sep 2012, accepted on 02 Oct 2012, published on 03 Oct 2012 and first published online on 03 Oct 2012


Article type: Communication
DOI: 10.1039/C2CC36513H
Citation: Chem. Commun., 2012,48, 11404-11406
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    Formation of chiral fluoroalkyl products through copper-free enantioselective allylic alkylation catalyzed by an NHC ligand

    D. Grassi, H. Li and A. Alexakis, Chem. Commun., 2012, 48, 11404
    DOI: 10.1039/C2CC36513H

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