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State Key Laboratory for Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong
E-mail: wing-yiu.yu@polyu.edu.hk
; Fax: +852 2364 9932
; Tel: +852 3400 8725
Chem. Commun., 2012,48, 11680-11682
DOI:
10.1039/C2CC36502B
Received
06 Sep 2012,
Accepted
16 Oct 2012
First published online
16 Oct 2012
An efficient method for synthesis of anthranilic acids by Pd-catalyzed ortho-C–H amidation of benzoic acids is disclosed. The amidation is proposed to proceed by carboxylate-assisted ortho-C–H palladation to form an arylpalladium(II) complex, followed by nitrene insertion to the Pd–C bond.