A novel pH activatable near-infrared fluorescence probe was developed, which successfully visualized acidosis in tumors. This probe holds promise to non-invasively predict the tumor metastasis potential and evaluate the therapeutic response.
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Imaging acidosis in tumors using a pH-activated near-infrared fluorescence probe
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a
Key Laboratory of Smart Drug Delivery, Ministry of Education & PLA, School of Pharmacy, Fudan University, 826 Zhangheng Rd, Shanghai 201203, China
E-mail: congli@fudan.edu.cn ;
Fax: +86 21 5198 0100 ;
Tel: +86 21 5198 0100
E-mail: congli@fudan.edu.cn ;
Fax: +86 21 5198 0100 ;
Tel: +86 21 5198 0100
b
Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, 1954 Huashang Rd, Shanghai 200030, China
E-mail: xwei01@sjtu.edu.cn ;
Fax: +86 21 62933072 ;
Tel: +86 21 62932302
E-mail: xwei01@sjtu.edu.cn ;
Fax: +86 21 62933072 ;
Tel: +86 21 62932302
Chem. Commun., 2012,48, 11677-11679
DOI: 10.1039/C2CC36488C
Received 05 Sep 2012, Accepted 12 Oct 2012
First published online 15 Oct 2012
Chemical Communications
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