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Issue 89, 2012
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Synthesis of selenomethylene-locked nucleic acid (SeLNA)-modified oligonucleotides by polymerases

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Abstract

Enzymatic recognition of SeLNA nucleotides was investigated. KOD XL DNA polymerase was found to be an efficient enzyme in primer extension reactions. Polymerase chain reaction (PCR) amplification of SeLNA-modified DNA templates was also efficiently achieved by Phusion and KOD XL DNA polymerases.

Graphical abstract: Synthesis of selenomethylene-locked nucleic acid (SeLNA)-modified oligonucleotides by polymerases

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Publication details

The article was received on 05 Sep 2012, accepted on 24 Sep 2012 and first published on 27 Sep 2012


Article type: Communication
DOI: 10.1039/C2CC36464F
Citation: Chem. Commun., 2012,48, 11020-11022
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    Synthesis of selenomethylene-locked nucleic acid (SeLNA)-modified oligonucleotides by polymerases

    M. Wheeler, A. Chardon, A. Goubet, K. Morihiro, S. Y. Tsan, S. L. Edwards, T. Kodama, S. Obika and R. N. Veedu, Chem. Commun., 2012, 48, 11020
    DOI: 10.1039/C2CC36464F

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