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Issue 8, 2013
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Copper-catalyzed C–N bond formation through C–H/N–H activation: a novel approach to the synthesis of multisubstituted ureas

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Abstract

A copper-catalyzed cross-dehydrogenative coupling reaction that involves C–H activation of formamides and N–H activation of N-alkoxy amides has been developed. This protocol affords a novel approach to the synthesis of multisubstituted ureas under mild conditions.

Graphical abstract: Copper-catalyzed C–N bond formation through C–H/N–H activation: a novel approach to the synthesis of multisubstituted ureas

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Publication details

The article was received on 03 Sep 2012, accepted on 20 Nov 2012 and first published on 22 Nov 2012


Article type: Communication
DOI: 10.1039/C2CC36417D
Citation: Chem. Commun., 2013,49, 819-821
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    Copper-catalyzed C–N bond formation through C–H/N–H activation: a novel approach to the synthesis of multisubstituted ureas

    H. Jiang, A. Lin, C. Zhu and Y. Cheng, Chem. Commun., 2013, 49, 819
    DOI: 10.1039/C2CC36417D

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