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Issue 2, 2013
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Rational design of Hg2+ controlled streptavidin-binding aptamer

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Abstract

Through substituting two canonical base pairs of a streptavidin-binding aptamer with T–T mismatched base pairs, a new aptamer was constructed. Its binding ability could be controlled by Hg2+ through the formation of T–Hg–T metal–base pairs.

Graphical abstract: Rational design of Hg2+ controlled streptavidin-binding aptamer

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Publication details

The article was received on 03 Sep 2012, accepted on 07 Nov 2012, published on 08 Nov 2012 and first published online on 08 Nov 2012


Article type: Communication
DOI: 10.1039/C2CC36416F
Citation: Chem. Commun., 2013,49, 164-166
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    Rational design of Hg2+ controlled streptavidin-binding aptamer

    H. Mei, T. Bing, C. Qi, N. Zhang, X. Liu, T. Chang, J. Yan and D. Shangguan, Chem. Commun., 2013, 49, 164
    DOI: 10.1039/C2CC36416F

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