A range of nucleoside phosphoramidites incorporating small amino substituents have been readily synthesised using ionic liquid stabilised phosphorodiamidites coupled with mechanochemistry.
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Nucleoside phosphitylation using ionic liquid stabilised phosphorodiamidites and mechanochemistry
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a
QUILL/School of Chemistry and Chemical Engineering, Queen's University, Belfast, UK
E-mail: c.hardacre@qub.ac.uk ;
Fax: +44 (0)2890974687
E-mail: c.hardacre@qub.ac.uk ;
Fax: +44 (0)2890974687
b
School of Pharmacy, Queen's University, Belfast, UK
E-mail: m.migaud@qub.ac.uk ;
Fax: +44 (0)28 90247794
E-mail: m.migaud@qub.ac.uk ;
Fax: +44 (0)28 90247794
Chem. Commun., 2012,48, 11969-11971
DOI: 10.1039/C2CC36367D
Received 31 Aug 2012, Accepted 24 Oct 2012
First published online 24 Oct 2012
This article is part of themed collection:
Mechanochemistry: fundamentals and applications in synthesis
Chemical Communications
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