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Dual catalysis mode for the dicarbonyl reduction catalyzed by diketoreductase

Meiling Lu,a   Yan Huang,a   Mark A. White,b   Xuri Wu,a   Nan Liu,a   Xiaodong Cheng*bc and   Yijun Chen*a  
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a
Laboratory of Chemical Biology and State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjia Street, Nanjing, People's Republic of China
E-mail: yjchen@cpu.edu.cn;
Fax: +86 25 83271031 ;
Tel: +86 25 83271045
b
Sealy Center for Structural Biology and Molecular Biophysics, The University of Texas Medical Branch, Galveston, USA
c
Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, USA
E-mail: xcheng@utmb.edu
Chem. Commun., 2012,48, 11352-11354

DOI: 10.1039/C2CC36334H
Received 31 Aug 2012, Accepted 08 Oct 2012
First published online 08 Oct 2012
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