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Issue 92, 2012
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Dual catalysis mode for the dicarbonyl reduction catalyzed by diketoreductase

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Abstract

Diketoreductase catalyzes a two-step bioreduction on a dicarbonyl substrate through a novel dual catalysis mode, in which random hydride attack simultaneously forms two mono-carbonyl intermediates, and subsequently distinct catalytic sites are responsible for the reductions of respective carbonyl group of the intermediates to yield the final dihydroxy product.

Graphical abstract: Dual catalysis mode for the dicarbonyl reduction catalyzed by diketoreductase

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Publication details

The article was received on 31 Aug 2012, accepted on 08 Oct 2012 and first published on 08 Oct 2012


Article type: Communication
DOI: 10.1039/C2CC36334H
Citation: Chem. Commun., 2012,48, 11352-11354
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    Dual catalysis mode for the dicarbonyl reduction catalyzed by diketoreductase

    M. Lu, Y. Huang, M. A. White, X. Wu, N. Liu, X. Cheng and Y. Chen, Chem. Commun., 2012, 48, 11352
    DOI: 10.1039/C2CC36334H

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