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Highly enantioselective organocatalytic Strecker reaction of cyclic N-acyl trifluoromethylketimines: synthesis of anti-HIV drug DPC 083

Fa-Guang Zhang,a   Xiao-Yan Zhu,a   Shen Li,a   Jing Niea and   Jun-An Ma*ab  
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a
Department of Chemistry, Tianjin University, Tianjin 300072, China
E-mail: majun_an68@tju.edu.cn;
Fax: +86-22-2740-3475
b
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry (CAS), Shanghai 200032, China
Chem. Commun., 2012,48, 11552-11554

DOI: 10.1039/C2CC36307K
Received 30 Aug 2012, Accepted 12 Oct 2012
First published online 23 Oct 2012
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