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Issue 94, 2012
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Highly enantioselective organocatalytic Strecker reaction of cyclic N-acyl trifluoromethylketimines: synthesis of anti-HIV drug DPC 083

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Abstract

A highly efficient, organocatalytic, enantioselective Strecker reaction of cyclic N-acyl ketimines was developed for the preparation of enantioenriched cyclic α-amino nitriles with a quaternary carbon stereocentre and anti-HIV drug DPC 083.

Graphical abstract: Highly enantioselective organocatalytic Strecker reaction of cyclic N-acyl trifluoromethylketimines: synthesis of anti-HIV drug DPC 083

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Publication details

The article was received on 30 Aug 2012, accepted on 12 Oct 2012 and first published on 23 Oct 2012


Article type: Communication
DOI: 10.1039/C2CC36307K
Citation: Chem. Commun., 2012,48, 11552-11554
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    Highly enantioselective organocatalytic Strecker reaction of cyclic N-acyl trifluoromethylketimines: synthesis of anti-HIV drug DPC 083

    F. Zhang, X. Zhu, S. Li, J. Nie and J. Ma, Chem. Commun., 2012, 48, 11552
    DOI: 10.1039/C2CC36307K

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