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Issue 91, 2012
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Synthesis of oligodeoxyribonucleotides containing a conformationally-locked anti analogue of O6-methyl-2′-deoxyguanosine and their recognition by MGMT and Atl1

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Abstract

We show that DNA containing a conformationally-locked anti analogue of O6-alkylguanine is a poor substrate for human O6-methylguanine–DNA methyltransferase (MGMT) and the alkyltransferase-like protein, Atl1. This highlights the requirement for the syn conformation and rationalises why certain O6-alkylguanines are poor MGMT substrates.

Graphical abstract: Synthesis of oligodeoxyribonucleotides containing a conformationally-locked anti analogue of O6-methyl-2′-deoxyguanosine and their recognition by MGMT and Atl1

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Publication details

The article was received on 28 Aug 2012, accepted on 01 Oct 2012 and first published on 11 Oct 2012


Article type: Communication
DOI: 10.1039/C2CC36252J
Citation: Chem. Commun., 2012,48, 11214-11216
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    Synthesis of oligodeoxyribonucleotides containing a conformationally-locked anti analogue of O6-methyl-2′-deoxyguanosine and their recognition by MGMT and Atl1

    K. Abdu, M. K. Aiertza, O. J. Wilkinson, J. A. Grasby, P. Senthong, A. C. Povey, G. P. Margison and D. M. Williams, Chem. Commun., 2012, 48, 11214
    DOI: 10.1039/C2CC36252J

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