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Issue 92, 2012
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Solid state grinding as a tool to aid enantiomeric resolution by cocrystallisation

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Abstract

The formation of diastereomeric cocrystals of malic acid and tartaric acid was investigated by liquid-assisted grinding in the solid state. We demonstrate that racemic malic acid can be converted into two distinct diastereomeric cocrystal phases by grinding with a single enantiomer of tartaric acid.

Graphical abstract: Solid state grinding as a tool to aid enantiomeric resolution by cocrystallisation

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Publication details

The article was received on 23 Aug 2012, accepted on 25 Sep 2012, published on 16 Oct 2012 and first published online on 16 Oct 2012


Article type: Communication
DOI: 10.1039/C2CC36130B
Citation: Chem. Commun., 2012,48, 11340-11342
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    Solid state grinding as a tool to aid enantiomeric resolution by cocrystallisation

    M. D. Eddleston, M. Arhangelskis, T. Friščić and W. Jones, Chem. Commun., 2012, 48, 11340
    DOI: 10.1039/C2CC36130B

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