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Issue 82, 2012
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Suppression of matrix ions by N-phosphorylation labeling using matrix-assisted laser desorption–ionization time-of-flight mass spectrometry

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Abstract

N-Phosphorylation labeling was utilized to analyze small metabolites using matrix-assisted laser desorption–ionization time-of-flight mass spectrometry (MALDI-TOF MS). The incorporation of a neutral phosphoryl group with high gas-phase proton affinity not only improved the ionization efficiency of the target molecules, but also greatly reduced the matrix background interference.

Graphical abstract: Suppression of matrix ions by N-phosphorylation labeling using matrix-assisted laser desorption–ionization time-of-flight mass spectrometry

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Publication details

The article was received on 19 Jul 2012, accepted on 29 Aug 2012 and first published on 29 Aug 2012


Article type: Communication
DOI: 10.1039/C2CC36091H
Citation: Chem. Commun., 2012,48, 10198-10200
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    Suppression of matrix ions by N-phosphorylation labeling using matrix-assisted laser desorption–ionization time-of-flight mass spectrometry

    X. Gao, Z. Tang, M. Lu, H. Liu, Y. Jiang, Y. Zhao and Z. Cai, Chem. Commun., 2012, 48, 10198
    DOI: 10.1039/C2CC36091H

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