Conserved RNA motifs of EMCV IRES as potential building blocks to design RNA nanostructures

Kwong Kit Chan; Vasudevan Ramesh

doi:10.1039/C2CC36034A

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Chemical Communications

Issue 94, 2012

Urgent high quality communications from across the chemical sciences.

Impact Factor 6.169 100 Issues per Year Indexed in MEDLINE

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Conserved RNA motifs of EMCV IRES as potential building blocks to design RNA nanostructures

Kwong Kit Chan^a and Vasudevan Ramesh*^a

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School of Chemistry, University of Manchester, Oxford Road, Manchester, UK
E-mail: vasudevan.ramesh@manchester.ac.uk ;
Fax: +44 (0)161 2754598 ;
Tel: +44 (0)161 3064539

Chem. Commun., 2012,48, 11573-11575

DOI: 10.1039/C2CC36034A
Received 20 Aug 2012, Accepted 15 Oct 2012
First published online 15 Oct 2012

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Abstract
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The highly conserved secondary structural RNA motifs endowed by the IRES element of EMCV picornavirus provide an excellent platform to design RNA nanostructures for application in medicine. We have identified a 44mer RNA, hosting distinct 15mer and 11mer RNA stem loop motifs, as potential building blocks for the design of RNA nanostructures.