We report a reagentless and reusable electrochemical DNA sensor that exploits competitive binding and target hybridization-induced change in the signalling probe conformation for robust detection of a target DNA sequence.
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A reagentless and reusable electrochemical DNA sensor based on target hybridization-induced stem-loop probe formation
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a
Key Laboratory of Green Chemical Engineering and Technology of College of Heilongjiang Province, College of Chemical and Environmental Engineering, Harbin University of Science and Technology, Harbin 150040, P. R. China
E-mail: yzgyh@126.com
E-mail: yzgyh@126.com
b
University of Nebraska-Lincoln, 651 Hamilton Hall, Lincoln, USA
E-mail: rlai2@unl.edu ;
Fax: +1 402 472 9402 ;
Tel: +1 402 472 5340
E-mail: rlai2@unl.edu ;
Fax: +1 402 472 9402 ;
Tel: +1 402 472 5340
Chem. Commun., 2012,48, 10523-10525
DOI: 10.1039/C2CC35985E
Received 18 Aug 2012, Accepted 05 Sep 2012
First published online 06 Sep 2012
Chemical Communications
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