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Issue 94, 2012
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Design of highly potent HIV fusion inhibitors based on artificial peptide sequences

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Abstract

Specific interactions were introduced between an artificial heptad repeat peptide template and HIV-1 gp41 for fusion inhibitor design, using a structure based rational design strategy. The designed peptides are nonhomologous with naturally occurring peptide and protein sequences, specifically interact with HIV-1 gp41, and show strong anti-HIV activity.

Graphical abstract: Design of highly potent HIV fusion inhibitors based on artificial peptide sequences

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Publication details

The article was received on 17 Aug 2012, accepted on 12 Oct 2012 and first published on 12 Oct 2012


Article type: Communication
DOI: 10.1039/C2CC35973A
Citation: Chem. Commun., 2012,48, 11579-11581
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    Design of highly potent HIV fusion inhibitors based on artificial peptide sequences

    W. Shi, L. Cai, L. Lu, C. Wang, K. Wang, L. Xu, S. Zhang, H. Han, X. Jiang, B. Zheng, S. Jiang and K. Liu, Chem. Commun., 2012, 48, 11579
    DOI: 10.1039/C2CC35973A

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