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Department of Medicinal Chemistry, Beijing Institute of Pharmacology & Toxicology, 27 Taiping Rd, Haidian District, China
; Fax: +86-10-68211656
Key Lab of Medical Molecular Virology (Ministries of Education and Health), Shanghai Medical College and Institute of Medical Microbiology, Fudan University 130 Dong An Road, Xuhui District, China
; Fax: +86-21-54237465
Chem. Commun., 2012,48, 11579-11581
17 Aug 2012,
12 Oct 2012
First published online
12 Oct 2012
Specific interactions were introduced between an artificial heptad repeat peptide template and HIV-1 gp41 for fusion inhibitor design, using a structure based rational design strategy. The designed peptides are nonhomologous with naturally occurring peptide and protein sequences, specifically interact with HIV-1 gp41, and show strong anti-HIV activity.
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