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Issue 90, 2012
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Heteroaromatic imidazo[1,2-a]pyridines synthesis from C–H/N–H oxidative cross-coupling/cyclization

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Abstract

A novel silver-mediated highly selective C–H/N–H oxidative cross-coupling/cyclization between 2-aminopyridines and terminal alkynes has been demonstrated. This approach provided a simple way to construct heteroaromatic imidazo[1,2-a]pyridines. By using this protocol, the marketed drug zolimidine (antiulcer) could be synthesized easily.

Graphical abstract: Heteroaromatic imidazo[1,2-a]pyridines synthesis from C–H/N–H oxidative cross-coupling/cyclization

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Publication details

The article was received on 16 Aug 2012, accepted on 12 Sep 2012 and first published on 13 Sep 2012


Article type: Communication
DOI: 10.1039/C2CC35927H
Citation: Chem. Commun., 2012,48, 11073-11075
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    Heteroaromatic imidazo[1,2-a]pyridines synthesis from C–H/N–H oxidative cross-coupling/cyclization

    C. He, J. Hao, H. Xu, Y. Mo, H. Liu, J. Han and A. Lei, Chem. Commun., 2012, 48, 11073
    DOI: 10.1039/C2CC35927H

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