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Chemical Communications

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Tuning efficiency of the 4-exo-trig cyclization by the electronic effect: ring closure of 3,3-difluoro-4-pentenyl carbon radicals and synthesis of a gem-difluorocyclobutane nucleoside

Corresponding authors
School of Pharmacy, Showa University, 1-5-8 Hatanodai, Tokyo 142-8555, Japan
E-mail: kumamoto@pharm.showa-u.ac.jp
Fax: +81-3-3784-8252
Tel: +81-3-3784-8187
Advanced Science Institute, NanomedicalEngineering Laboratory, RIKEN, 2-1 Hirasawa, Saitama 351-0198, Japan
Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium
Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 89-8544, Japan
Chem. Commun., 2012,48, 10993-10995

DOI: 10.1039/C2CC35876J
Received 14 Aug 2012, Accepted 20 Sep 2012
First published online 24 Sep 2012
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