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Issue 90, 2012
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Transformation of an antimicrobial peptide into a plasma membrane-permeable, mitochondria-targeted peptide via the substitution of lysine with arginine

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Abstract

Simple substitution of D-lysine with D-arginine in antimicrobial peptide (RLA) considerably improved its membrane permeability and increased mitochondrial accumulation. The potential use of RLA in preventing apoptotic cell death is also demonstrated through delivery of the Bcl-xL BH4 domain peptide.

Graphical abstract: Transformation of an antimicrobial peptide into a plasma membrane-permeable, mitochondria-targeted peptide via the substitution of lysine with arginine

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Publication details

The article was received on 14 Aug 2012, accepted on 25 Sep 2012 and first published on 26 Sep 2012


Article type: Communication
DOI: 10.1039/C2CC35872G
Citation: Chem. Commun., 2012,48, 11097-11099
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    Transformation of an antimicrobial peptide into a plasma membrane-permeable, mitochondria-targeted peptide via the substitution of lysine with arginine

    I. Nakase, S. Okumura, S. Katayama, H. Hirose, S. Pujals, H. Yamaguchi, S. Arakawa, S. Shimizu and S. Futaki, Chem. Commun., 2012, 48, 11097
    DOI: 10.1039/C2CC35872G

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