Characterization of structural changes in aptamer films for controlled release nanodevices

M. Belén Serrano-Santos; Eduard Llobet; Veli C. Özalp; Thomas Schäfer

doi:10.1039/C2CC35683J

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Chemical Communications

Issue 81, 2012

Urgent high quality communications from across the chemical sciences.

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Characterization of structural changes in aptamer films for controlled release nanodevices

M. Belén Serrano-Santos,*^a Eduard Llobet,^a Veli C. Özalp^b and Thomas Schäfer^b^c

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EMaS, Department of Electronic, Electric and Automation Engineering, University Rovira i Virgili, Avda. Països Catalans 26, 43007 Tarragona, Spain
E-mail: mariabelen.serrano@urv.cat

NanoBioSeparations Group, POLYMAT, University of the Basque Country UPV/EHU, Avda. Tolosa 72, 20018 Donostia-San Sebastián, Spain
E-mail: thomas_schafer@ehu.es ;
Fax: +34 943015347 ;
Tel: +34 943018266

Basque Foundation for Science, Bilbao, Spain

Chem. Commun., 2012,48, 10087-10089

DOI: 10.1039/C2CC35683J
Received 06 Aug 2012, Accepted 21 Aug 2012
First published online 21 Aug 2012

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The dimension of the conformational changes of DNA-aptamers which can be used as stimulus-responsive gate-keepers in controlled delivery nanodevices has been determined by acoustic wave-based sensors upon molecular recognition of a small-sized target, adenosine-5′-monophosphate (AMP).

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