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Issue 91, 2012
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Multifaceted folding in a foldamer featuring highly cooperative folds

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Abstract

Herein, we report on the folding pattern observed in a synthetic peptide featuring two highly mutually dependent, yet strikingly dissimilar, closed networks of hydrogen-bonded rings that work in a cumulative fashion to stabilize the entire folded architecture of the peptide. Structural studies unequivocally suggest that disruption of any one of these mutually-dependent hydrogen-bonded networks is deleterious to the stability of the fully folded conformation of the peptide.

Graphical abstract: Multifaceted folding in a foldamer featuring highly cooperative folds

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Publication details

The article was received on 03 Aug 2012, accepted on 25 Sep 2012 and first published on 26 Sep 2012


Article type: Communication
DOI: 10.1039/C2CC35649J
Citation: Chem. Commun., 2012,48, 11205-11207
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    Multifaceted folding in a foldamer featuring highly cooperative folds

    V. V. E. Ramesh, G. Priya, A. S. Kotmale, R. G. Gonnade, P. R. Rajamohanan and G. J. Sanjayan, Chem. Commun., 2012, 48, 11205
    DOI: 10.1039/C2CC35649J

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