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Issue 80, 2012
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Sensitive analysis of DNA methyltransferase based on a hairpin-shaped DNAzyme

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Abstract

The analysis of DNA methylation and MTase (methyltransferase) activity is important in epigenetic study. We have developed a novel strategy for sensitive analysis of MTase activity based on a hairpin shaped DNAzyme; 8–17 DNAzyme amplicon has been adopted and found to be very effective in such analysis.

Graphical abstract: Sensitive analysis of DNA methyltransferase based on a hairpin-shaped DNAzyme

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Publication details

The article was received on 14 Jul 2012, accepted on 22 Aug 2012 and first published on 23 Aug 2012


Article type: Communication
DOI: 10.1039/C2CC35648A
Citation: Chem. Commun., 2012,48, 10031-10033
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    Sensitive analysis of DNA methyltransferase based on a hairpin-shaped DNAzyme

    T. Tian, H. Xiao, Y. Long, X. Zhang, S. Wang, X. Zhou, S. Liu and X. Zhou, Chem. Commun., 2012, 48, 10031
    DOI: 10.1039/C2CC35648A

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