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Issue 80, 2012
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Enantioselective organocatalytic domino synthesis of tetrahydropyridin-2-ols

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Abstract

The asymmetric synthesis of tetrahydropyridin-2-ols from enals and enaminones is described. The organocatalytic domino reaction involves a Michael addition–hemiaminalization sequence using the Jørgensen–Hayashi catalyst. Dehydration or oxidation leads to the corresponding 1,4-dihydro-pyridines or 3,4-dihydropyridin-2-ones in a one-pot fashion.

Graphical abstract: Enantioselective organocatalytic domino synthesis of tetrahydropyridin-2-ols

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Publication details

The article was received on 03 Aug 2012, accepted on 22 Aug 2012 and first published on 22 Aug 2012


Article type: Communication
DOI: 10.1039/C2CC35644A
Citation: Chem. Commun., 2012,48, 10049-10051
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    Enantioselective organocatalytic domino synthesis of tetrahydropyridin-2-ols

    J. Wan, C. C. J. Loh, F. Pan and D. Enders, Chem. Commun., 2012, 48, 10049
    DOI: 10.1039/C2CC35644A

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