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Issue 97, 2012
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Local orientational disorder in peptide fibrils probed by a combination of residue-specific 13C–18O labelling, polarised infrared spectroscopy and molecular combing

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Abstract

A novel combination of site-specific isotope labelling, polarised infrared spectroscopy and molecular combing reveals local orientational ordering in the fibril-forming peptide YTIAALLSPYSGGRADS. Use of 13C–18O labelled alanine residues demonstrates that the N-terminal end of the peptide is incorporated into the cross-beta structure, while the C-terminal end shows orientational disorder.

Graphical abstract: Local orientational disorder in peptide fibrils probed by a combination of residue-specific 13C–18O labelling, polarised infrared spectroscopy and molecular combing

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Publication details

The article was received on 01 Aug 2012, accepted on 22 Aug 2012 and first published on 23 Aug 2012


Article type: Communication
DOI: 10.1039/C2CC35586H
Citation: Chem. Commun., 2012,48, 11835-11837
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    Local orientational disorder in peptide fibrils probed by a combination of residue-specific 13C–18O labelling, polarised infrared spectroscopy and molecular combing

    J. C. Rodríguez-Pérez, I. W. Hamley, S. L. Gras and A. M. Squires, Chem. Commun., 2012, 48, 11835
    DOI: 10.1039/C2CC35586H

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