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Issue 91, 2012
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Point-to-helical chirality transfer for a scalable and resolution-free synthesis of a helicenoidal DMAP organocatalyst

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Abstract

The synthesis of a second-generation [6]-helicenoidal DMAP organocatalyst is reported. The synthesis is reliant upon a highly diastereoselective Rh-catalysed [2 + 2 + 2] triyne cycloisomerization, using an existing stereocentre to control the sense of forming helicity. Taken together, a scalable (>1 g), resolution-free entry to a helical DMAP with the capacity for subsequent functionalization, has been achieved.

Graphical abstract: Point-to-helical chirality transfer for a scalable and resolution-free synthesis of a helicenoidal DMAP organocatalyst

  • This article is part of the themed collection: Chirality
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Publication details

The article was received on 01 Aug 2012, accepted on 23 Aug 2012 and first published on 24 Aug 2012


Article type: Communication
DOI: 10.1039/C2CC35583C
Citation: Chem. Commun., 2012,48, 11181-11183
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    Point-to-helical chirality transfer for a scalable and resolution-free synthesis of a helicenoidal DMAP organocatalyst

    M. R. Crittall, N. W. G. Fairhurst and D. R. Carbery, Chem. Commun., 2012, 48, 11181
    DOI: 10.1039/C2CC35583C

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