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Issue 96, 2012
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Atomic force microscopy captures folded ribosome bound nascent chains

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Abstract

Direct visualization of co-translational folding of nascent polypeptide chains is challenging. Here we present, for the first time, AFM images of large protein constructs based on the membrane binding domain of ankyrin-R, complexed with the ribosome. The characteristic “horse-shoe” shape of ankyrin-R emerging from the ribosome was captured.

Graphical abstract: Atomic force microscopy captures folded ribosome bound nascent chains

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Publication details

The article was received on 31 Jul 2012, accepted on 25 Sep 2012 and first published on 26 Sep 2012


Article type: Communication
DOI: 10.1039/C2CC35551E
Citation: Chem. Commun., 2012,48, 11727-11729
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    Atomic force microscopy captures folded ribosome bound nascent chains

    A. Loksztejn, Z. Scholl and P. E. Marszalek, Chem. Commun., 2012, 48, 11727
    DOI: 10.1039/C2CC35551E

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